Glucosamine HCl
The form used in the largest independent trial, where it did not beat placebo.
What it’s good for
Glucosamine HCl for Joint Pain
No Benefit3 studies · 0 supporting · 3 against
How it was tested: The largest independent trial of these supplements. Glucosamine hydrochloride and chondroitin, alone or together, were no better than placebo overall. A subgroup with worse pain did better, which the authors themselves called preliminary.
The same proposed mechanism as the sulfate; the salt differs, and so did the result.
Dose: 1500 mg
Tested as: glucosamine hydrochloride 1500 mg daily, given as 500 mg three times a day