Strong evidenceamino_acid
Glycine for Insomnia
Glycine acts on NMDA receptors in the suprachiasmatic nucleus to lower core body temperature, a key signal for sleep initiation. It also increases serotonin levels in the prefrontal cortex and enhances slow-wave sleep quality.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
Research source
SourceYamadera W et al. · Sleep and Biological Rhythms 2007How much to take
3000 mg
Take 3g before bed. Can be dissolved in water or taken as capsules. Generally very well tolerated.
When to take it
Best taken: evening