Profhilo / Juvelook / Lenisna
A next-generation injectable hyaluronic acid that differs fundamentally from traditional fillers: rather than adding volume, it is a pure ultra-high-molecular-weight HA that spreads through tissue to hydrate and bio-remodel the skin by stimulating production of collagen, elastin and adipocytes.
How it works
Unlike cross-linked HA fillers designed to stay in place, Profhilo contains a thermally cross-linked HA that bio-integrates and spreads beneath the skin. It stimulates four types of collagen (I, III, IV, VII), elastin production, and adipocyte growth factor — comprehensively remodelling the extracellular matrix rather than simply filling. Distributed via the BAP (Bio-Aesthetic Points) technique at 5 injection points per side.
Reported benefits
- Skin hydration and moisture barrier restoration
- Skin laxity improvement (face, neck, hands, body)
- Fine line reduction through tissue remodelling
- Skin glow and luminosity enhancement
- Collagen and elastin stimulation
- Safe for all skin types and tones (no pigmentation risk)
Regulatory status
Approved for: Skin laxity treatment, Skin bio-remodelling, Facial rejuvenation
Profhilo (IBSA Group) is CE-marked as a Class III medical device in the EU since ~2015. Very widely used across Italy, UK, Germany, Spain. Has become one of the most popular aesthetic injectables in Europe.
Approved for: Skin laxity and bio-remodelling, Facial skin quality improvement
Profhilo is MHRA-registered and widely available in the UK through aesthetic clinics. One of the most popular treatments in UK aesthetics. Must be administered by licensed practitioners under Health and Care Act 2022.
Approved for: Hyaluronic acid fillers — general FDA approval for facial use
Profhilo (IBSA) does not have a separate FDA approval. It may be used under the broader FDA clearance for HA-based dermal fillers as a Class III medical device. More established in EU/UK; FDA approval pathway pending/uncertain.
Practical details
Frequency: Initial protocol: 2 sessions, 4 weeks apart; maintenance every 6 months
Results last: Hydration visible within 1 week; full remodelling results at 2 months after course; lasts 6–12 months
Contraindications:
- Active infection or inflammation at injection site
- Allergy to hyaluronic acid or bacterial components
- Pregnancy or breastfeeding
- Blood thinning medications (mild bruising risk)
Always consult a licensed medical professional before undergoing any treatment. This information is educational only and does not constitute medical advice.