NAD+ IV
Intravenous infusion of Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme found in all living cells that is central to energy metabolism, DNA repair, and cellular signaling.
How it works
NAD+ is a critical cofactor for sirtuins (anti-aging proteins), PARP (DNA repair enzymes), and the mitochondrial electron transport chain. Levels naturally decline with age; IV delivery restores cellular NAD+ pools rapidly. Activates SIRT1 and SIRT3 pathways linked to longevity.
Reported benefits
- Increased mental clarity and cognitive function
- Energy and mitochondrial function restoration
- Anti-aging and cellular repair support
- Athletic performance and recovery
- Addiction recovery support (off-label)
- Mood improvement and stress resilience
Regulatory status
No EMA approval. Available in some EU countries through specialist wellness clinics under physician supervision. Regulatory status varies by member state.
IV NAD+ must be prescribed by a registered physician in the UK. Not licensed as a medicine for any indication. Available at specialist anti-aging and longevity clinics.
Approved for: Addiction therapy (limited evidence, off-label), Investigational use in clinical trials
NAD+ is classified by FDA as a dietary supplement precursor (NMN, NR) orally, but IV NAD+ is in a grey area. Not FDA approved as a drug for any indication. Available through compounding pharmacies with physician prescription. Clinical trials ongoing for neurodegenerative diseases.
Practical details
Frequency: Loading series of 4–10 sessions; monthly maintenance
Results last: Cognitive effects noticed during infusion; energy improvements last 1–4 weeks
Contraindications:
- Pregnancy or breastfeeding
- Active cancer (NAD+ fuels cellular growth)
- Kidney disease
- Hypersensitivity to niacin
- Blood pressure instability (can cause flushing)
Always consult a licensed medical professional before undergoing any treatment. This information is educational only and does not constitute medical advice.