antioxidant · for dry skin
Glutathione
Meant to protect skin cells from damage and help them hold moisture.
Say that in clinical terms
Modulates melanin synthesis pathways, provides antioxidant protection to skin cells, enhances dermal hydration.
How strong is the research?
1 paper read.
Tested as: Glutathione (Plain Oral, Reduced)
Who was studied: Studied in liver disease patients.
The research we could find tested Glutathione (Plain Oral, Reduced). That is a different preparation, and a result for one form is not a result for another.
How much to take
daily
250–500 mg
Skin lightening is a common side effect. Combine with adequate hydration.
Before you take it
- No NIH ODS Tolerable Upper Intake Level (UL) has been established for glutathione; neither oral nor liposomal forms carry an established UL.
- Potential interaction with cisplatin and other platinum-based chemotherapy agents: glutathione-S-transferases can conjugate GSH with cisplatin, and elevated intracellular glutathione correlates with platinum-based drug resistance; patients receiving oncology protocols should consult a physician before supplementing.
- Insufficient clinical safety data for glutathione supplementation at supplemental doses during pregnancy and lactation.
- Long-term safety of chronic oral or liposomal glutathione supplementation at supplemental doses has not been established in clinical trials.
What we make of it
A gastroenterology study in liver patients, measuring neither skin nor moisture.
The detail
The trial appeared in a liver journal, enrolled liver disease patients, and measured markers of oxidative stress. Skin hydration was not among its outcomes.