Phosphatidylserine
What it’s good for
Phosphatidylserine for Poor Memory
Evidence3 studies · 3 supporting · 0 against
Phosphatidylserine is a phospholipid concentrated in neuronal cell membranes; supplementing it is theorized to support membrane fluidity and cell signaling involved in memory formation, though the human mechanism is not firmly established.
Dose: 100–300 mg
Tested as: Soy-derived phosphatidylserine 100-300 mg/day, and a PS-omega-3/DHA complex around 300 mg/day, for 6 weeks to 6 months
Phosphatidylserine for Anxiety
No Benefit1 study · 0 supporting · 1 against
How it was tested: PAS 400mg normalized ACTH and cortisol stress-hormone responses in high-stress subjects, but there was no significant effect on psychological stress/anxiety measures (STAI-X1, VAS) or mood; funded by Lipogen Ltd and Lonza Ltd, with two authors disclosing commercial interests
Theorized to blunt the HPA-axis (cortisol/ACTH) hormonal stress response, which could plausibly reduce anxiety — but the trial below found the hormone change did not translate into people actually feeling less anxious.
Dose: 200–400 mg
Tested as: Soy-based phosphatidylserine/phosphatidic acid complex (PAS) 200 mg or 400 mg/day for 42 days