other · for anxiety
Phosphatidylserine
Meant to blunt the cortisol response to stress — but the trial found the hormones did not move.
Say that in clinical terms
Theorized to blunt the HPA-axis (cortisol/ACTH) hormonal stress response, which could plausibly reduce anxiety — but the trial below found the hormone change did not translate into people actually feeling less anxious.
How strong is the research?
No Benefit evidence
It did normalise the stress hormones. It made no difference to how anxious people actually felt.
Low-quality evidence
1 paper read, 1 against.
Tested as: Soy-based phosphatidylserine/phosphatidic acid complex (PAS) 200 mg or 400 mg/day for 42 days
Who was studied: Healthy men under long-running stress.
How much to take
200–400 mg