No Benefit evidenceother
Phosphatidylserine for Anxiety
Theorized to blunt the HPA-axis (cortisol/ACTH) hormonal stress response, which could plausibly reduce anxiety — but the trial below found the hormone change did not translate into people actually feeling less anxious.
How strong is the research?
No Benefit evidence
PAS 400mg normalized ACTH and cortisol stress-hormone responses in high-stress subjects, but there was no significant effect on psychological stress/anxiety measures (STAI-X1, VAS) or mood; funded by Lipogen Ltd and Lonza Ltd, with two authors disclosing commercial interests
How much to take
200–400 mg