Strong evidenceherb
Rhodiola for Stress
Rhodiola activates the adaptive stress-response pathway via HSP70 and FOXO/DAF-16 signaling. It modulates cortisol release, enhances catecholamine signaling, and prevents stress-induced depletion of norepinephrine and serotonin.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
How much to take
200–400 mg
Standardized extract (SHR-5). Take early in the day as it can be mildly stimulating. Pairs well with ashwagandha.
When to take it
Best taken: morning