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S-Equol
What it’s good for
S-Equol for Hot Flashes
No Benefit3 studies · 2 supporting · 1 against
How it was tested: The Menopause Society names equol as not recommended for hot flushes.
A stronger, more targeted version of the soy compounds it is made from.
Dose: 10–40 mg
Tested as: S-equol (natural, soy-fermentation-derived; e.g. SE5-OH), 10 mg or 40 mg/day, generally tested against soy isoflavones rather than placebo alone. Benefit is concentrated in equol nonproducers - roughly 70-80% of Western women, whose gut bacteria cannot convert the soy isoflavone daidzein into equol.