Red Clover Isoflavones40–82 mg · any
Plant compounds that weakly mimic oestrogen, meant to offset the drop that triggers flushes.
No benefit foundResearch →
mood mental health · symptom
Hot Flashes
Sudden heat, flushing and sweating, often at night.
Tested — didn’t work
Measured properly against placebo. Nothing found.6Measured properly against placebo. Nothing found.
Black Cohosh40–160 mg · any
Thought to act on the brain’s thermostat rather than on oestrogen, though that is debated.
No benefit foundResearch →
Evening Primrose Oil500–1000 mg · any
Its active fat is thought to act on the signals that widen blood vessels during a flush.
No benefit foundResearch →
Soy Isoflavones30–100 mg · any
Plant compounds that weakly bind oestrogen receptors, meant to steady the brain’s thermostat.
No benefit foundResearch →
S-Equol10–40 mg · any
A stronger, more targeted version of the soy compounds it is made from.
No benefit foundResearch →
Flaxseed50–410 mg · any
Gut bacteria turn its lignans into weak oestrogen-like compounds.
No benefit foundResearch →
No research yet
People take these for it. We haven’t found trials we would stand behind.3People take these for it. We haven’t found trials we would stand behind.
Saffron28 mg · any
No trials we can vouch forResearch →
Vitamin E400 IU · with_food
An antioxidant effect on the brain’s thermostat is proposed, but never really pinned down.
No trials we can vouch forResearch →
Calcium1000 mg · split
No trials we can vouch forResearch →