No Benefit evidenceenzyme
Nattokinase for High Cholesterol
Nattokinase's proposed cardiovascular actions (reducing fibrin, blood viscosity, mild renin suppression) do not target LDL production or clearance pathways, which may explain why it does not move cholesterol numbers on its own.
How strong is the research?
No Benefit evidence
Low-dose nattokinase increased total cholesterol (MD +5.27, p<0.00001) and decreased HDL-C (MD -2.76, p<0.00001) vs placebo; high-dose nattokinase also increased total cholesterol (MD +3.18, p<0.00001); no significant effect on triglycerides
How much to take
1200–4000 mg