enzyme · for high cholesterol
Nattokinase
Its effects on blood thickness were expected to show up in cholesterol too.
Say that in clinical terms
Nattokinase's proposed cardiovascular actions (reducing fibrin, blood viscosity, mild renin suppression) do not target LDL production or clearance pathways, which may explain why it does not move cholesterol numbers on its own.
How strong is the research?
Low-dose nattokinase raised total cholesterol and lowered the good kind — the wrong direction.
2 papers read, 2 against.
Tested as: Nattokinase 1,200-4,000 FU/day tested alone in pooled trials — note FU (fibrinolytic units) is not mg. A separate trial tested 2,500 FU/day combined with 7 mg lovastatin-equivalent from red yeast rice (Monascus), not nattokinase alone.
Who was studied: Adults with raised cholesterol.
How much to take
1200–4000 mg