other1 of 1 uses with evidence behind them
Soy Isoflavones
What it’s good for
Soy Isoflavones for Hot Flashes
No Benefit4 studies · 2 supporting · 2 against
How it was tested: Soy foods and soy extracts are classified as 'not recommended' for vasomotor symptoms (Level I evidence).
Isoflavones are plant compounds that weakly bind estrogen receptors, partially compensating for the estrogen decline that destabilizes the brain's temperature-control center; genistein binds estrogen-receptor-beta more selectively than other soy isoflavones.
Dose: 30–100 mg
Tested as: standardized soy isoflavone extracts, 40-100 mg total isoflavones/day in most trials; the more consistent positive signal came from genistein-predominant extracts specifically (30-54 mg genistein/day), not mixed isoflavone blends or soy food/diet counseling.