Strong evidencevitamin
Vitamin B1 for Chronic Fatigue
Essential cofactor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, enabling cellular energy production from glucose.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
How much to take
50–100 mg
High-dose thiamine (benfotiamine form) may be more effective. Take on empty stomach.
When to take it
Best taken: morning