Moderate evidencevitamin
Vitamin B12 for Low Mood
B12 is required for SAMe regeneration through methionine synthase. Deficiency causes elevated homocysteine and impaired methylation, reducing synthesis of serotonin, dopamine, and norepinephrine, all key mood-regulating neurotransmitters.
How strong is the research?
Moderate evidence
Based on cohort study data — strong observational evidence.
Research source
SourceSangle P et al. · Cureus 2020How much to take
1000–2000 mcg
Works synergistically with folate. Test levels if on metformin, PPIs, or following a vegetarian diet.
When to take it
Best taken: morning