Strong evidencefatty_acid
Omega-3 for Low Mood
EPA reduces neuroinflammation via resolvin and protectin synthesis, enhances serotonin receptor sensitivity, and modulates HPA axis function. Low omega-3 status is consistently associated with depression in epidemiological studies.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceLiao Y et al. · Translational Psychiatry 2019How much to take
1000–2000 mg
EPA-predominant formulas (at least 60% EPA) show strongest antidepressant effects. Allow 8-12 weeks for mood improvement.
When to take it
Best taken: with food