Strong evidencevitamin
Vitamin D for Low Mood
Vitamin D receptors are expressed throughout the brain, including mood-regulating regions. Vitamin D modulates serotonin synthesis via tryptophan hydroxylase-2 activation and influences BDNF expression, neuroplasticity, and HPA axis regulation.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceSpedding S · Nutrients 2014How much to take
2000–4000 IU
Test 25(OH)D levels and aim for 40-60 ng/mL. Higher doses may be needed initially if deficient. Take with fat for absorption.
When to take it
Best taken: morning