Strong evidenceamino_acid
5-HTP for Low Mood
Direct precursor to serotonin, bypassing rate-limiting tryptophan hydroxylase step. Crosses BBB readily.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
5-Hydroxytryptophan: a clinically-effective serotonin precursor · 1998How much to take
50–300 mg
Start low (50mg) and titrate up. Do NOT combine with SSRIs/MAOIs (serotonin syndrome risk).