Strong evidenceherb
Ashwagandha for Stress
Ashwagandha is a premier adaptogen that modulates the HPA axis, reducing cortisol secretion by 23-30%. It mimics GABA at GABA-A receptors and enhances stress resilience through BDNF upregulation and neuroprotection.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
How much to take
300–600 mg
The most studied adaptogen for stress. KSM-66 is the best-studied extract. Take consistently for best results.
When to take it
Best taken: evening