herb5 cited usesBest taken: evening

Ashwagandha

A full-spectrum root extract of Withania somnifera standardized to 5% withanolides. An adaptogen clinically shown to reduce cortisol, anxiety, and stress while improving sleep, energy, and endurance.

What it’s good for

AnxietyStrong

Ashwagandha modulates the HPA axis, reducing cortisol levels by up to 30%. Its withanolides act as GABA-mimetics, binding to GABA-A receptors, and also modulate serotonin pathways, producing significant anxiolytic effects.

Dose: 300–600 mg

Ashwagandha reduces cortisol by up to 30% and modulates GABAergic signaling, both of which help stabilize mood and reduce stress-induced irritability. It also supports serotonin receptor balance.

Dose: 300–600 mg

StressStrong

Ashwagandha is a premier adaptogen that modulates the HPA axis, reducing cortisol secretion by 23-30%. It mimics GABA at GABA-A receptors and enhances stress resilience through BDNF upregulation and neuroprotection.

Dose: 300–600 mg

InsomniaStrong

Ashwagandha contains triethylene glycol which induces non-rapid eye movement sleep. It also reduces cortisol levels, addressing stress-induced insomnia, and modulates GABAergic pathways to promote sleep onset and duration.

Dose: 300–600 mg

Ashwagandha improves sleep quality via cortisol reduction, GABAergic modulation, and the sleep-inducing compound triethylene glycol. Studies show significant improvements in Pittsburgh Sleep Quality Index scores.

Dose: 300–600 mg

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