Strong evidencemineral
Iron for Chronic Fatigue
Iron is essential for hemoglobin (oxygen transport) and myoglobin (muscle oxygen storage). It is also a cofactor in mitochondrial cytochrome enzymes for ATP production. Iron deficiency is the most common cause of correctable fatigue worldwide.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceVaucher P et al. · BMJ 2012How much to take
18–36 mg
MUST test ferritin levels before supplementing. Take on empty stomach or with vitamin C. Avoid with calcium, tea, or coffee. Target ferritin >50 ng/mL.
When to take it
Best taken: empty stomach