Strong evidencehormone
Melatonin for Insomnia
Binds to MT1 and MT2 receptors in suprachiasmatic nucleus, phase-shifting circadian rhythm and reducing sleep onset latency.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceFerracioli-Oda E et al. · PLoS ONE 2013How much to take
0.5–5 mg
Lower doses (0.5-1mg) often sufficient. Take 30-60 minutes before desired sleep time. Not habit-forming.