Strong evidencevitamin
Vitamin B12 for Headaches/Migraines
Elevated homocysteine is associated with increased migraine frequency. B12, along with folate and B6, lowers homocysteine through the methionine synthase pathway, reducing vascular inflammation and endothelial dysfunction.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
Research source
SourceLea R et al. · Pharmacogenetics and Genomics 2009How much to take
1000 mcg
Often combined with folate and B6 for homocysteine lowering. May be especially helpful for migraines with aura.
When to take it
Best taken: morning