Strong evidencefatty_acid
Omega-3 for Headaches/Migraines
High-dose omega-3 fatty acids reduce production of pro-inflammatory eicosanoids (prostaglandins, thromboxanes) from arachidonic acid, and produce anti-inflammatory resolvins and protectins that reduce neurogenic inflammation in migraine.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
Research source
SourceRamsden CE et al. · BMJ 2021How much to take
1800–2400 mg
Higher doses (EPA 1200mg + DHA 600mg) showed best results in migraine trials. Take with food.
When to take it
Best taken: with food