Strong evidencevitamin
Vitamin B2 for Headaches/Migraines
Enhances mitochondrial energy production via FAD and FMN coenzymes, correcting energy deficits in cortical neurons that trigger migraines.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
How much to take
200–400 mg
High-dose riboflavin is first-line migraine prophylaxis. Takes 2-3 months for full effect.
When to take it
Best taken: morning