Strong evidenceantioxidant
CoQ10 for Headaches/Migraines
CoQ10 improves mitochondrial energy production in neurons, reduces oxidative stress, and inhibits CGRP release. Brain energy deficiency and oxidative stress are key pathogenic factors in migraine.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
Research source
SourceSandor PS et al. · Cephalalgia 2005How much to take
100–300 mg
Ubiquinol form is better absorbed. Take with a fat-containing meal. Allow 4-12 weeks for migraine prevention effects.
When to take it
Best taken: with food