Strong evidenceherb
Ashwagandha for Anxiety
Ashwagandha modulates the HPA axis, reducing cortisol levels by up to 30%. Its withanolides act as GABA-mimetics, binding to GABA-A receptors, and also modulate serotonin pathways, producing significant anxiolytic effects.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
How much to take
300–600 mg
KSM-66 standardized to 5% withanolides. Can be taken morning and evening. Allow 4-8 weeks for full effect.
When to take it
Best taken: evening