Strong evidencevitamin
Folate for Low Mood
Folate is essential for SAMe synthesis, the primary methyl donor for monoamine neurotransmitter production (serotonin, dopamine, norepinephrine). Low folate status impairs methylation and is strongly associated with depression.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
How much to take
800–1000 mcg
L-methylfolate (5-MTHF) bypasses MTHFR polymorphisms. Often used as adjunct to antidepressant therapy. Do not exceed 1000mcg without medical guidance.
When to take it
Best taken: morning