Moderate evidencevitamin
Vitamin K2 MK-4 for Joint Pain
Carboxylates osteocalcin and MGP, preventing calcium accumulation in cartilage and supporting bone-cartilage interface integrity.
How strong is the research?
Moderate evidence
Based on cohort study data — strong observational evidence.
Research source
SourceIwamoto J et al. · Nutrition Journal 2016How much to take
15–45 mg
MK-4 requires higher doses than MK-7 due to shorter half-life. Divide into 3 doses.
When to take it
Best taken: with food