Strong evidenceherb
Curcumin for Chronic Inflammation
Curcumin is a pleiotropic anti-inflammatory that inhibits NF-kB (master inflammatory switch), COX-2, LOX, iNOS, and multiple inflammatory cytokines (TNF-alpha, IL-1, IL-6, IL-8). It also activates Nrf2 antioxidant response and modulates over 100 molecular targets.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceHewlings SJ et al. · Foods 2017How much to take
500–1000 mg
Use a bioavailability-enhanced form. Curcumin is one of the most potent natural anti-inflammatories studied.
When to take it
Best taken: with food