Strong evidencefatty_acid
Omega-3 for Chronic Inflammation
EPA and DHA are substrates for specialized pro-resolving mediators (resolvins, protectins, maresins) that actively resolve inflammation. They compete with arachidonic acid for COX/LOX enzymes, reducing pro-inflammatory prostaglandin and leukotriene synthesis.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceCalder PC · Biochimica et Biophysica Acta 2015How much to take
2000–3000 mg
Higher doses (2-3g) for significant inflammatory reduction. EPA is the more anti-inflammatory omega-3.
When to take it
Best taken: with food