Strong evidencemineral
Magnesium Glycinate for Irritability
Magnesium modulates NMDA receptors, preventing glutamate excitotoxicity that contributes to irritability. It also regulates the HPA stress axis and supports GABA receptor function, promoting emotional stability.
How strong is the research?
Strong evidence
Based on a randomised controlled trial (RCT) — the gold standard for establishing cause and effect.
Research source
SourcePickering G et al. · Nutrients 2020How much to take
300–400 mg
Magnesium deficiency is very common and frequently manifests as irritability. Glycinate form is calming and well-tolerated.
When to take it
Best taken: evening