Moderate evidenceamino_acid

N-Acetyl Cysteine for Joint Pain

NAC replenishes glutathione in chondrocytes, protecting cartilage from oxidative degradation. It inhibits NF-kB and MMP activity in joint tissues, reduces IL-1beta-induced cartilage catabolism, and may slow osteoarthritic cartilage breakdown.

How strong is the research?

Moderate evidence

Based on a clinical trial with human participants.

Research source

SourceYusuf E et al. · Osteoarthritis and Cartilage 2017

How much to take

600–1200 mg

NAC supports cartilage health through glutathione-mediated antioxidant protection and anti-inflammatory effects.

All uses of N-Acetyl CysteineAll supplements for Joint Pain

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