Strong evidencevitamin
Vitamin D for Chronic Inflammation
Vitamin D modulates both innate and adaptive immune responses, shifting the balance from pro-inflammatory Th1/Th17 to anti-inflammatory Th2/Treg responses. It suppresses NF-kB, reduces TNF-alpha, IL-6, and CRP, and enhances anti-inflammatory IL-10.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceBiesalski HK · Nutrients 2020How much to take
2000–4000 IU
Vitamin D deficiency is strongly associated with elevated inflammatory markers. Test and optimize levels.
When to take it
Best taken: morning