Strong evidenceamino_acid
N-Acetyl Cysteine for Chronic Inflammation
NAC is the rate-limiting precursor for glutathione synthesis, the body's primary endogenous antioxidant. It directly inhibits NF-kB activation, reduces oxidative stress-driven inflammatory cascades, and decreases CRP, IL-6, and TNF-alpha levels.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
Research source
SourceTardiolo G et al. · Molecules 2018How much to take
600–1800 mg
NAC replenishes glutathione, the master antioxidant. Take on empty stomach. Start at 600mg and increase.