Strong evidencemineral
Zinc for Acne
Zinc reduces 5-alpha reductase activity (lowering DHT-driven sebum), inhibits P. acnes bacterial growth, modulates inflammatory TLR-2 signaling, and reduces keratinocyte activation and comedone formation. Comparable to low-dose antibiotics.
How strong is the research?
Strong evidence
Based on a meta-analysis of multiple studies — the highest level of research evidence.
How much to take
30–50 mg
Higher therapeutic doses (30-50mg) for 2-3 months, then reduce to 15-30mg maintenance. Balance with 1-2mg copper if using >30mg.
When to take it
Best taken: empty stomach